The native peoples of North America, sometimes referred to as American Indians or First Nations.

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What are the factors that caused the new world civilizations to be less technologically advanced than the old world?

Assuming they started at the same point (maybe the split of the continents or the migration of the first "Native Americans" to the American continent), why did the Old World end up developing faster? ...
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To what extent did Native American cultures develop metalworking for tools and weapons?

When Europeans started showing up in the New World, the native cultures were technologically far behind. Many still used stone tools: North American tribes used flint, while some Mesoamerican cultures ...
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New World Sickness

When Europeans came to the Americas, they brought with them "Old World diseases" that decimated the Native American population. There's a big list of them here. Were there any "New World" diseases ...
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Why is Christopher Columbus credited for “discovering” America?

Even if we ignore the millions of native Americans who lived in the continent before Columbus "discovered" it, even if we ignore other civilizations (eg: Polynesians, Phoenicians, Chinese, Arabs, ...
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Early instances of bacteriological warfare

Via The Straight Dope, I came across this page which claims that Lord Jeffrey Amherst, commander-in-chief of the Brits in America seriously considered distributing blankets infected with small-pox to ...