I'm going to answer this question by relying on data from places like New England and New York. I think patterns in New England should be fairly similar to those in Pennsylvania, with the provisoexception that the Appalachians and Alleghenies in PA are a more formidable barrier than the Berkshires. You can see some evidence of this in the isoclimes from the Atlas of Historical Geography's estimated rates of travel from New York City in 1800:
Someone from Lancaster could reach Philadelphia in about two days, and from Philly it would be easy to get anywhere along the Eastern seaboard. But the isoclimes really bunch around the Appalachians, and that isn't going to get much easier until engineers figure out how to get railroads to climb over the steep gradients of some of these mountains. The difficultdifficulty of such a feat is one reason why NYC overtook Philly as the country's largest city.
Still, thisWhile the above map tells us about capabilities, but this question is about "typical" travels. A good source for such a question comes from Winifred Rothenberg's studies of the movements of Massachusetts farmers, published in 1981 in the Journal of Economic History.
The first thing we learn from Rothenberg is that from 1750-1855, the vast majority of trips are around 10-25 miles in length (see note below)distance traveled. By the early 19th century, there are a fair number of longer trips (around 80 miles), but these never predominate. See thisThis hard-to-read graph of farmers' trips frequenciessummarizes the frequency of trip lengths by distance traveledperiods:
And what does this distribution look like for individual farmers? Here are the travel histories of five farmers:
Keep in mind that throughout this entire period, there is a steady drive westward. Younger sons who didn't inherit the family farm in Rhode Island might move to Rochester, NY, and later to or the Western Reserve in Ohio. For example, Paul Johnson's A Shopkeeper's Millenium has a fairly detailed accounting of the origins of families in Rochester, NY in the 1820s. Most still had close relatives in New England.
The late colonial and early national United States were a fairly well-integrated society. If you thought you'd murdered someone and went on the lam like Simon Kenton, you would need to keep moving West along with the always-receding frontier. Yet while long interstate trips were occasional events in most Americans' lives, the farmers' data show that your "typical" daily routine was still fairly limited geographically by the difficulty of travel.