Today I learned that Swedish king Gustav III supposedly took two twin brothers that had been convicted for murder and had them drink three pots of coffee and tea respectively per day. He supposedly did this to prove that coffee was bad for you, but ironically he got assassinated before either of the brother died.
However, there seems to be no contemporary records of this twin study so we don't know if it really happened. But that leads me to the question: What was the first documented twin study?
Wikipedia references one in 1905, but that seems to be more about studying twins, than doing the type of twin study where you use twins to look for environmental factors, which is what Gustav III did.