Unidentified ship possibly numbered 545, aircraft carrier in background, maybe San Francisco or Washington State?
The stern is much too low to be an LSM. I'm 99% sure that it's LSI(L)-545, likely prior to departing for New Guinea in late summer of 1944. It was an LSI 341 class transport (class prototype below):
The bridge looks like the Golden Gate, but the only angle that would be right for that shot would make the island Alcatraz and I'm thinking that the buildings would be visible from that angle.
EDIT: After taking another scan around the San Francisco bay, it is possible that the photo was taken from the Mile Rocks lighthouse from roughly this direction, catching only the north tower of the bridge and zooming in on the departing ships:
UPDATE: I was totally wrong on the picture location. @AndyW correctly pointed out in his answer (and received my much deserved up vote) that this is the San Francisco Bay Bridge and Yerba Buena Island. Here's the same shot from Google Maps Street View.
It is USS LSIL-545. It got two battle commendations. Here is that baby in action in New Guinea (what a hell hole):
The New Guinea campaign was complete hell. During wartime censorship (what First Ammendment?) Roosevelt permitted photographs of dead soldiers for the first time from this campaign (notice landing craft in the background):
The front number looks like 545. For the location there is text on the island, something like:
WE XXXX GREAT WORK
hth, maybe someone remembers it.
Also found this guy asking the same: