Comino, the smallest of the three Maltese islands, is covered in terraces and walls, which seems to indicate that at one time the entire island was heavily occupied and cultivated. As late as the 19th century I found notices that watermelons from Comino were well regarded.
However, currently, the island is unpopulated except for two hotels and a couple of tourist spots.
I know that various islands in the Mediterranean like Sardinia and the Balaerics suffered terrible massacres and raids by the Barbary pirates from 1400-1800. Was this the fate of Comino? Wiped out by Barbary pirates? Or was the depopulation a more modern phenomenon?