The Otomi'. the Tlaxcalan, the Nahua (Aztecs), the Tarasca, the Zapotec, the Huastec, the Totonac, the Mejica, and the Mixtec all knew pulque (Poohl - kei), which is derived from the self-fermenting sap of the highland Maguey....a larege, rough relative of the lilly family. Alcohol content varies according to sub-species, elevation (high or higher...5,000 to 8,000 fasl) but can range from 6% to 15%. It was reserved, usually for the priests and leading warriors and aristocracy / royalty of the primordial Toltec, who are correctly associated with the Pyramids of Teotihuacan, northeast of Mexico City about 35 miles. (The famous pyramids)
The Quicholes (Huichole) incorporated peyote in their "religious" celebrations and activities, most of it drawn from the Sierra de Catorce in San Luis Postosi State of Mexico. And, most of the northern, very remote Indians such as the Rararuri (aka - Tarahumara) have their corn-mash "tezquino" a gross dishwater whiskey of highly variable quality and potency, Mayo, Yaqui, Mescalero and other Apaches did make another form of Maguey-based firewater known as Mescal. Mescal is also produced in Oaxaca by descendants of the Zapotecs. Mescal can have a proofage of 110 up to 140. When sugar cane began to be produced in Mexico rum was begun as a distillate with some popularity, but the local people preferred the much more powerful "aguardiente" or "burning water". Mescal, for bonded and disciplined sale, can still be found in 100 or 105 proofage in Oaxaca. It is both milder and more potent than people might suspect....it is also very "organic".
All of the above, save for rum, of course, were present when the first Spanish explorers arrived into Mexico, beginning in the early 1520s.