Yellow fever outbreaks were frequent in the southern US in the late C18th. The 1793 Philadelphia epidemic was one of the most severe outbreaks of infectious disease in US history, killing 10% of the residents of the city and causing 40% to flee (more information on that outbreak here).
Some time ago, I remember reading that this epidemic played a significant role in the decision to move the capital from Philadelphia to Washington DC. Looking into it in more detail (I'd like to use it as an example in a forthcoming lecture), it sounds like it would be more accurate to say that the capital was already due to move to Washington DC as a result of the Residence Act of 1790, but that the Philadelphians were lobbying to reverse that decision during the 1790s, and ultimately the YF epidemic was a factor in their failure to get a reversal reconsidered.
There are more details on the move from Philadelphia to DC in this article by the US National Constitution Centre. However, the only place YF is mentioned , it simply states "a yellow fever epidemic hit Philadelphia in 1793, raising doubts about the safety of the area". It doesn't say who had those doubts, how we know about them or what actual effect they had, if any, on decisions about the move.
It seems plausible that such a massive public health problem could influence decisions on this topic if there was still any plausible chance of reversal, although it is equally apparent that there were other significant factors in favour of a move to DC.
Did the 1793 YF epidemic or (more broadly) the history of YF epidemics in the region affect any appeals regarding the move, or is there any evidence that public support for the move to DC was strengthened on the basis of the threat from YF?