That's a difficult question to answer, as for part of the 17th century Zeeuws Vlaanderen was a war zone. In theory people would go to Antwerpen, Brugge or Gent. In reality, no. Because of the 80 years war. Travelling to Middelburg was more likely, but much more difficult, as they had to cross the Westerschelde. Travelling further, to Rotterdam or Amsterdam was an even more difficult voyage lasting several days.
The area was ruled by the Staten Generaal directly, as Generaliteitsland. That should give you a clear idea this was not a run-of-the-mill province, where people could wander wherever they wanted.
It's possible some trade was going on locally with Spanish Flanders, but all official business was done either from The Hague (States General) or Middelburg (County of Zeeland). No doubt there was some contact, but regular contact definitely not.
Before 1604, when the area was conquered by the Dutch, it was an outright war zone. Until 1648, treaty of Munster, progressively more traffic. After 1648, peace was established. After that more traffic was possible.
Zeeuws or Staats Vlaanderen (link is in Dutch) orientated itself in this period to the Dutch Republic, not to Vlaanderen.