The empresario system started way before Mexico was independent, so the answer will depend on whether you consider empresarios appointed by Spain as counting or not. If so then, Philip Alston, in 1790, was appointed an empresario in New Madrid (Missouri) and before him George Morgan was appointed empresario there by Spain.
European Americans renamed the settlement New Madrid in about 1780
under the auspices of Spanish Governor Bernardo de Gálvez, who was
appointed to rule Spanish Louisiana (the land west of the Mississippi
River), and Manuel Pérez, Lieutenant Governor of Upper Louisiana in
Saint Louis. They welcomed settlers from the United States, but
required them to become subjects of the Spanish crown. In addition,
they had to agree to live under the guidance of his appointed
empresario, Colonel George Morgan, an American Revolutionary War
veteran from New Jersey. Morgan recruited a number of American
families to settle at New Madrid, attracting a few hundred people to
the region. link